melanocyte development and pigmentation pathway
| PAG Title | melanocyte development and pigmentation pathway |
| PAG ID | WAG000627 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Studies with homozygous knockout mice have suggested that stem cell factor (SCF or KITLG), c-Kit, microphthalmia (Mitf), and B-cell CLL/lymphoma 2 (Bcl2) genes regulates melanocytic development. The SCF activation of Kit receptor leads to Mitf phosphorylation through MAP kise pathway. The activated Mitf recruits p300 and up-regulates Bcl2 transcription, which plays an important role in modulating the development and survival of the melanocyte lineage. |
| Species | Homo sapiens |
| nCoCo Score | 1,446 |
| Base PAG ID | WAG000627 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
">
Something else? Please send us an email!